Lab of Cancer RNA Biology 로고_3.png
  • Introduction

  • Members

    • Professor
    • Members
  • Alumni

    • Paper
  • Publication

    • 논문
    • 특허
    • 학술대회
  • Research

    • Oncogenomics
    • Epigenetic Regulation
    • RNomics
    • Predictive and Discovery Genomics
  • Education

    • Cancer
    • Oncogenes
  • Board

    • Gallery
  • More

    Use tab to navigate through the menu items.
    실제 작동 상태를 확인하려면 라이브 사이트로 이동하세요.
    • 전체 게시물
    • 내 게시물
    oncogenomics lab
    2018년 3월 02일

    김정규 박사, 한빛사 논문 등극 (Mol. Cell 2017)

    게시판: BOARD

    Mol. Cell, Available online 14 December 2017 | https://doi.org/10.1016/j.molcel.2017.11.021

    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

     Authors and Affiliations

    Abstract Recent integrative epigenome analyses highlight the importance of functionally distinct chromatin states for accurate cell function. How these states are established and maintained is a matter of intense investigation. Here, we present evidence for DNA damage as an unexpected means to shape a protective chromatin environment at regions of recurrent replication stress (RS). Upon aberrant fork stalling, DNA damage signaling and concomitant H2AX phosphorylation coordinate the FACT-dependent deposition of macroH2A1.2, a histone variant that promotes DNA repair by homologous recombination (HR). MacroH2A1.2, in turn, facilitates the accumulation of the tumor suppressor and HR effector BRCA1 at replication forks to protect from RS-induced DNA damage. Consequently, replicating primary cells steadily accrue macroH2A1.2 at fragile regions, whereas macroH2A1.2 loss in these cells triggers DNA damage signaling-dependent senescence, a hallmark of RS. Altogether, our findings demonstrate that recurrent DNA damage contributes to the chromatin landscape to ensure the epigenomic integrity of dividing cells.

    논문정보 - 형식: Research article - 게재일: 2017년 12월 (BRIC 등록일 2017-12-20) - 연구진: 국외연구진 - 분야: Molecular_Biology, Cell_Biology, Genomics

    댓글 0개
    0
    댓글 0개

    서울시 서초구 반포대로 222 가톨릭대학교 성의교정 / TEL : 02-2258-7448 / FAX : 02-537-6586

    222 Banpo-daero Seocho-gu, Seoul, (06591) Republic of korea / TEL : +82-2-2258-7448 / FAX : +82-2-537-6586