Lab of Cancer RNA Biology 로고_3.png
  • Introduction

  • Members

    • Professor
    • Members
  • Alumni

    • Paper
  • Publication

    • 논문
    • 특허
    • 학술대회
  • Research

    • Oncogenomics
    • Epigenetic Regulation
    • RNomics
    • Predictive and Discovery Genomics
  • Education

    • Cancer
    • Oncogenes
  • Board

    • Gallery
  • More

    Use tab to navigate through the menu items.
    실제 작동 상태를 확인하려면 라이브 사이트로 이동하세요.
    • 전체 게시물
    • 내 게시물
    oncogenomics lab
    2019년 3월 13일
      ·  수정: 2019년 3월 13일

    김정규 박사, 한빛사 논문 등극! (Nat. Struct. Mol. Biol., 2019)

    게시판: BOARD

    김정규 박사, 한빛사 논문 등극!


    Nat. Struct. Mol. Biol., Published 04 March 2019, 26, pages 213-219 | https://doi.org/10.1038/s41594-019-0192-3The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening Authors and Affiliations

    Abstract

    The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere-maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Recently, we identified a protective role for the ATRX-interacting macroH2A1.2 histone variant during homologous recombination and replication stress (RS). Consistent with an inherent susceptibility to RS, we show that human ALT telomeres are highly enriched for macroH2A1.2. However, in contrast to ATRX-proficient cells, ALT telomeres transiently lose macroH2A1.2 during acute RS to facilitate DNA double-strand break (DSB) formation, a process that is almost completely prevented by ectopic ATRX expression. Telomeric macroH2A1.2 is re-deposited in a DNA damage response (DDR)-dependent manner to promote homologous recombination-associated ALT pathways. Our findings thus identify the dynamic exchange of macroH2A1.2 on chromatin as an epigenetic link among ATRX loss, RS-induced DDR initiation and telomere maintenance via homologous recombination.


    http://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=56850&idauthorid=22836&Page=1&BackLink=L2hhbmJpdHNhL3RyZWF0aXNlX2luZGV4LnBocD9QYWdlPTE=


    댓글 0개
    0
    댓글 0개

    서울시 서초구 반포대로 222 가톨릭대학교 성의교정 / TEL : 02-2258-7448 / FAX : 02-537-6586

    222 Banpo-daero Seocho-gu, Seoul, (06591) Republic of korea / TEL : +82-2-2258-7448 / FAX : +82-2-537-6586