서울시 서초구 반포대로 222 가톨릭대학교 성의교정 / TEL : 02-2258-7114 / FAX : 02-532-6537

222 Banpo-daero Seocho-gu, Seoul, (06591) Republic of korea / TEL : +82-2-2258-7114 / FAX : +82-2-532-6537

oncogenomics lab
2018년 7월 17일

노지헌 박사, 한빛사 논문 등극(Genes Dev. 2018)

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Genes Dev., July 1, 2018, 32: 909-914 | doi: 10.1101/gad.313270.118

SCAMP4 enhances the senescent cell secretome

Authors and Affiliations

Abstract The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 (SCAMP4) levels were strikingly elevated on the surface of senescent cells compared with proliferating cells. Interestingly, silencing SCAMP4 in senescent fibroblasts reduced the secretion of SASP factors, including interleukin 6 (IL6), IL8, growth differentiation factor 15 (GDF-15), C-X-C motif chemokine ligand 1 (CXCL1), and IL7, while, conversely, SCAMP4 overexpression in proliferating fibroblasts increased SASP factor secretion. Our results indicate that SCAMP4 accumulates on the surface of senescent cells, promotes SASP factor secretion, and critically enhances the SASP phenotype.

Keywords : human diploid fibroblasts, SCAMP4, senescence-associated secretory phenotype (SASP), cellular senescence

논문정보- 형식: Research article - 게재일: 2018년 07월 (BRIC 등록일 2018-07-06) - 연구진: 국외연구진 - 분야: Cell_Biology, Developmental_Biology, Genetics

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