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    oncogenomics lab
    2018년 7월 17일

    노지헌 박사, 한빛사 논문 등극(Genes Dev. 2018)

    게시판: BOARD

    Genes Dev., July 1, 2018, 32: 909-914 | doi: 10.1101/gad.313270.118

    SCAMP4 enhances the senescent cell secretome

    Authors and Affiliations

    Abstract The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 (SCAMP4) levels were strikingly elevated on the surface of senescent cells compared with proliferating cells. Interestingly, silencing SCAMP4 in senescent fibroblasts reduced the secretion of SASP factors, including interleukin 6 (IL6), IL8, growth differentiation factor 15 (GDF-15), C-X-C motif chemokine ligand 1 (CXCL1), and IL7, while, conversely, SCAMP4 overexpression in proliferating fibroblasts increased SASP factor secretion. Our results indicate that SCAMP4 accumulates on the surface of senescent cells, promotes SASP factor secretion, and critically enhances the SASP phenotype.

    Keywords : human diploid fibroblasts, SCAMP4, senescence-associated secretory phenotype (SASP), cellular senescence

    논문정보- 형식: Research article - 게재일: 2018년 07월 (BRIC 등록일 2018-07-06) - 연구진: 국외연구진 - 분야: Cell_Biology, Developmental_Biology, Genetics

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