서울시 서초구 반포대로 222 가톨릭대학교 성의교정 / TEL : 02-2258-7114 / FAX : 02-532-6537

222 Banpo-daero Seocho-gu, Seoul, (06591) Republic of korea / TEL : +82-2-2258-7114 / FAX : +82-2-532-6537

oncogenomics lab
2018년 2월 12일

양희두 박사과정생, 은정우 박사 EMM(IF:5.063) 논문 게재!

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수정: 2018년 2월 12일

T-cell immune regulator 1 enhances metastasis in hepatocellular carcinoma.

Experimental & Molecular Medicine (2018) 50, e420 (2018)

doi:10.1038/emm.2017.166

Received:21 April 2017 Accepted:11 May 2017 Published online:05 January 2018

 

AbstractAbstract

Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent HCC tissues from HCC patients who underwent partial or total hepatectomy and from non-metastatic primary HCC tissues. From this, we were able to identify genes associated with HCC recurrence. TCIRG1 (T-Cell Immune Regulator 1) was one of the aberrantly overexpressed genes in patients with recurrent HCC who had undergone total hepatectomy. The significant overexpression of TCIRG1 was confirmed using the Liver Hepatocellular Carcinoma dataset from The Cancer Genome Atlas. High expression of TCIRG1 was significantly associated with poor 5-year disease-free and recurrence-free survival of HCC patients. TCIRG1 knockdown suppressed tumor cell growth and proliferation in HCC cell lines; caused a significant increase in the proportion of cells in the G1/S phase of cell cycle; induced cell death; suppressed the metastatic potential of HCC cells by selectively regulating the epithelial–mesenchymal transition (EMT) regulatory proteins E-cadherin, N-cadherin, Fibronectin, Snail and Slug; and significantly attenuated the metastatic potential of ras-transformed NIH-3T3 cells in vitro and in vivo. These findings suggest that TCIRG1 functions as a metastatic enhancer by modulating growth, death and EMT in HCC cells. TCIRG1 could be a therapeutic target for the treatment of liver malignancy and metastasis.

 

 

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